Formulation and characterization of microemulsion system. Pseudoternaryphase diagrams were constructed to determine the microemulsion existence region using surfactant tween 80. Microemulsion region from pseudoternary phase diagram was selected for miglyol 810. Throughout the article, two distinct gels, made of two different microemulsion droplets r. Upon mild agitation followed by dilution in aqueous media, such as gastrointestinal gi fluids, the systems can form fine oil in water ow microemulsions which usually have a droplet size less than 100 nm. Characterization of microemulsions prepared using isopropyl. Solutol hs 15 system highest region was found in 1.
Preparation of nano and microemulsions using phase inversion. Cs meant for comparative evaluation of mmebased systems was prepared by. Preparation and evaluation of nanoemulsion formulation by using spontaneous emulsification deepa dhiman, amit kumar pal, aman mittal, sunit saini department of pharmacy, smt. Various ow and wo microemulsions of diclofenac diethylammonium were prepared by.
Any change in colour and transparency or phase separation occurred during normal storage condition 372. Preparation of nano and microemulsions using phase inversion and emulsion titration methods. The right blend of low and high hlb s leads to the formation of a stable me formulation. For modified lecithin, the microemulsion contains at least one metal chelate complex, at least one surfactant such as an anionic surfactant, modified lecithin, water, and optionally at least one alcohol.
Optimization, development and evaluation of microemulsion for the release of combination of guaifenesin and phenylephrine s. Optimization of polymer concentration for preparation of microemulsionbased hydrogel. This may be considered as an extension of w insors classification form ing the fifth category. Mandal baroda college of pharmacy, vadodara, india. Introduction since from the past years, the oral drug delivery system has been taken to a new extent with the. This book provides an assessment of some issues influencing the characteristics and performance of the microemulsions, as well as their main types of applications. The majority of microemulsions use oil and water as immiscible liquid pairs. This invention also relates to microemulsion preconcentrates and microemulsions that contain a lipophilic functional ingredient formulated with the microemulsifying system, and to processes for preparing the microemulsion preconcentrates and microemulsions. Moreover, the microemulsion with and without catechin showed less irritant properties when compared with the standard irritant group. Interfacial tension, measurement, effect of surfactant on oilwater interface. Full text preparation and evaluation of microemulsion. Pdf the purpose of the current research was to prepare and evaluate the potential use of microemulsionbased hydrogel mbh formulations for dermal.
The amount of surfactant and cosurfactant to be added and the percent of oil. Salicylic acid sa is a keratolytic agent used in topical products with antimicrobial actions. The mucoadhesive microemulsion formulation of olanzapine that contains. Formulation and evaluation of microemulsion based tablets of acyclovir for better patient compliance jatin dedakia, shivprasad h. A potential novel drug delivery system jaspreet kaur saini 1, ujjwal nautiyal 1, senthil kumar m 1, devendra singh 2, firoz anwar 3 1department of pharmaceutics, himachal institute of pharmacy, paonta sahib, himachal pradesh, india. Development of a novel microemulsion for oral absorption enhancement of alltrans retinoic acid thirapit subongkot,1 tanasait ngawhirunpat2 1department of pharmaceutical technology, faculty of pharmaceutical sciences, burapha university, chonburi, thailand. Microemulsion systems containing bioactive natural oils. Formulation and evaluation of microemulsionbased hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Design and formulation of optimized microemulsions for. Microemulsion domains are usually characterized by constructing ternaryphase diagrams. Optimization, development and evaluation of microemulsion for. Optimization, development and evaluation of microemulsion. Oilinwater mes were formulated using surfactant s peg8 capryliccapric glycerides and cosurfactant cos polyglyceryl6isostearate.
The optimized microemulsion was composed of karanj oil 9%, span 20 41%, capryol 90 41% and water 9%. Microemulsion is a nanoparticle synthesis technique in which two immiscible fluids such as water in oil wo, oil in water ow or water in supercritical carbon dioxide wsc co2 are thermodynamically stabilized with the aid of a surfactant. Biointerfaces on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Preparation and evaluation of microemulsionbased transdermal. Characterization of microemulsion the formulated microemulsion exhibited mean droplet size of 35. Microemulsions may be defined as oil dispersed in water or water dispersed in oil. Evaluation of microemulsion 1922 a microscopic evaluation microscopic analysis was carried out in order to observe the homogeneity of microemulsion formulations. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of microemulsion factors affecting. Microemulsion preconcentrates and microemulsions, and.
Three components are the basic requirement to form a microemulsion. Preparation, optimization and characterization of microemulsions 167 5. Jan 18, 2008 the present studies were designed to develop a formulation of amphotericin b in a lipidbased preparation as a microemulsion and to compare its toxicity with the commercial formulation fungizone. Development and evaluation of a microemulsion formulation for. The objective of this work was to prepare and evaluate sa me systems. Preparation of microemulsion microemulsions were prepared at 27c by a titration method. Nanoemulsions comprising an aqueous phase and a lipid phase, having a micelle size in the range from about 20 to about 900 nm and comprising melatonin as an active agent, are provided. In vivo and in vitro biocompatibility study of novel microemulsion. After the addition of each drop, the mixture was stirred and observed.
Oil and the water phases can be combined with surfactant and a cosurfactant is then added at slow rate with gradual stirring untill the system is transparent. Preparation of drug solution the olz solution os meant for comparative evaluation of mmebased systems was prepared by dissolving olz 80 mg in 10 ml of propylene glycol resulting in a solution of 8 mgml kumar et al. May 01, 2014 read preparation and optimization of voriconazole microemulsion for ocular delivery, colloids and surfaces b. For other materials, the microemulsion contains all above plus one. Microemulsions, which are optically isotropic and thermodynamically stable systems of water, oil, surfactant, and cosurfactant, can. Preparation and evaluation of cilnidipine microemulsion. Formulation, optimization and evaluation of atorvastatin calcium loaded microemulsion. The rapidly increasing number of applications for microemulsions has kept this relatively old topic still at the top point of research themes. Formulation and evaluation of microemulsion based delivery. Design and formulation of optimized microemulsions for dermal.
Formulation and evaluation of microemulsionsbased drug. Microemulsions combine the advantages of emulsions with those of. Preparation and evaluation of microemulsion systems containing. Preparation of drug loaded formulations the drug loaded microemulsion formulations were prepared by.
Knotted polymer chain in solution produces nanosized 15 nm latex particles smaller than those obtainable by emulsion polymerization paint the walls of a microporous material dry. Majumdar sptm, svkms nmims, shirpur, dhule 425 405, maharashtra, india. Preparation of nicotinamide microemulsions and formulation. The microemulsion system thus, shows a structural change from oil continuous system to water continuous, which has higher viscosities than the former 34. It belongs to the ii class of bcs classification hence formulating a microemulsion will increase its solubility dissolution and thus improves the oral bioavailability. The microemulsion was optimized on the basis of the transparency, drug release profile and particle size. Preparation and evaluation of microemulsion containing antihypertensive drug article pdf available in international journal of applied pharmaceutics 105. Preparation of nano and microemulsions using phase. Pharmacodynamic evaluation also indicated lesser intensity of seizures in rats treated with optimized formulation in comparison to rats treated with oral carbamazepine microemulsion and nasal carbamazepine solution which suggested carbamazepine transnasal delivery system as an effective alternate therapy for treatment of epilepsy. An me gel base composed of 35% ipm, 20% water, and 45% tween 80. Microemulsions mes are clear, thermodynamically stable systems.
Us20120251596a1 nanoemulsion, method for its preparation. The result showed that the microemulsion is a suitable carrier for catechin topical application. Preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. Modified ow microemulsions were prepared by tween80 and. Formulation in microemulsions mes containing natural oils. Vedha hari department of pharmaceutical technology, scbt, sastra university, thanjavur6401.
To enhance the solubility and bioavailability of poorly absorbable fexofenadine, microemulsion system composed of oil, surfactant and cosurfactant was developed for intranasal delivery. The aim of study was to develop a microemulsion based tablets to increase the solubility. Microemulsion formulation design and evaluation for. Preparation and evaluation of nanoemulsion formulation by. Sep 09, 2009 preparation of the microemulsion base and microemulsion systems containing different concentrations of salicylic acid. The microemulsions can be used in the development and manufacture of new healthcare. Microemulsions are easily prepared and require no energy contribution during preparation this is due to better thermodynamic stability. Preparation and evaluation of microemulsionbased transdermal delivery of total flavone of rhizoma arisaematis lina shen,1 yongtai zhang,1 qin wang,2 ling xu,2 nianping feng11department of pharmaceutical sciences, 2department of oncology, longhua hospital, shanghai university of traditional chinese medicine, shanghai, peoples republic of chinaabstract. Full text development of a novel microemulsion for oral. Pdf on oct 10, 2012, mohammed asadullah jahangir and others published preparation.
Formulation and evaluation of microemulsion based topical. Pharmaceutical technology, faculty of pharmacy, silpakorn university, nakhon pathom, thailand abstract. The drugloaded microemulsion formulation was stable for at least 3 months of storage at 25 c. Interfacial tension, measurement, effect of surfactant on. Formulation and characterization of microemulsion based. The final product developed is a lyophilized amphotericin b, oil and surfactant blend for reconstitution in water to yield a microemulsion containing 5 mgml of the drug. Historical background definition composition of microemulsion major goals advantages disadvantages macroemulsion vs microemulsion types of microemulsions preparation methods of microemulsions equipments used for the preparation of microemulsions formation of. They may become unstable at low or high temperature but when the temperature. Read preparation and optimization of voriconazole microemulsion for ocular delivery, colloids and surfaces b.
Phase behavior, particle size, viscosity and solubilization. Preparation of drug loaded formulations the drug loaded microemulsion formulations were prepared by incorporating the drugs phenylephrine and guaifenesin in the previously prepared blank formulations. A platform for improving dissolution rate of poorly water soluble drug surjyanarayan mandal and snigdha. The prepared microemulsions were evaluated for globule size, viscosity, ph. Formulation and evaluation of microemulsionbased hydrogel. Pdf preparation and evaluation of novel microemulsionbased. Formulation and characteristics of nicotinamideloaded microemulsions. Preparation and evaluation of microemulsion systems. Pdf formulation and evaluation of microemulsionbased. For topical delivery semisolid preparation are widely accepted over solid and liquid dosage forms. Optimization of polymer concentration for preparation of microemulsion based hydrogel. Microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. The wo me was successfully formulated with a surfactant blend.
By joining the change points, the boundaries of phases formed were obtained in. Atorvastatin calcium is a hmgcoa inhibitor having an antihyperlipidemic effect. They are formed spontaneously upon mixing a suitable oil, water, and an amphiphile blend surfactants either alone or in combination with a. In this study, we selected blend of surfactants containing. Preparation, optimization and characterization of microemulsions microemulsions are isotropic systems, which are difficult to formulate than ordinary emulsions because their formulation is a highly specific process involving. The polymer for preparation of microemulsion based hydrogel was optimized on the basis of viscosity and 2% of hpmc k100m was selected as the suitable polymer concentration to provide sustained release of bifonazole from the microemulsion based hydrogel. The objective of this study was to formulate optimal formulations of microemulsions mes and evaluate their feasibility for delivery of resveratrol into human skin ex vivo.
They were used to solubilize drugs and to improve topical drug availability. Pdf preparation and evaluation of fluconazole topical. Definition and history one of the best definitions of microemulsions is from danielsson and lindman 1 a microemulsion is a system of water, oil and an amphiphile which is a single optically isotropic and thermodynamically stable liquid solution. Preparation and evaluation of transnasal microemulsion of.
Formulation and evaluation of microemulsion based topical hydrogel containing lornoxicam biswajit biswal1, nabin karna 1, jyotiranjan nayak2, vivek joshi 1dept. Preparation and evaluation of fluconazole topical microemulsion article pdf available in journal of pharmacy research 23 january 2009 with 1,206 reads how we measure reads. Dec 28, 2015 microemulsion is an isotropic mixture of oil, surfactant, cosurfactant and drug. Microemulsion was prepared using constant ratio of surfactant sco surfactant cos, various combinations of oil and scos were produced. Formulation and evaluation of nanoemulsion of amphotericin b harika k, subhashis debnath, m niranjan babu department of pharmaceutics, seven hills college of pharmacy, venkatramapuram, tirupathi 517561, andhra pradesh, india. Formulation, optimization and evaluation of atorvastatin. These types of formulations combine the advantages of micro. Microemulsion formulations have distinct advantages over macroemulsion systems when delivered parenterally because of the fine particle microemulsion is cleared more slowly than the coarse particle emulsion and, therefore, have a longer residence time in the body. September october 2010 indian journal of pharmaceutical sciences 637 development and evaluation of artemether parenteral microemulsion. Both ow and wo microemulsion can be used for parenteral delivery. The aim of the present study was to prepare and evaluate different formulations of. The present invention provides a storage stable microemulsion formulation for modified lecithin as well as other materials.
Polymerization in a confined environment may lead to unique polymer morphologies, e. The primary aim of the present study was to develop a novel microemulsion me formulation to deliver phenylethanoid glycoside pg. Formulation and characterization of microemulsion based gel. Preparation and characterization of nicotinamideloaded microemulsions 35 3. The polymer for preparation of microemulsionbased hydrogel was optimized on the basis of viscosity and 2% of hpmc k100m was selected as the suitable polymer concentration to provide sustained release of bifonazole from the microemulsionbased hydrogel. Microemulsion me formulation how to develop a microemulsion me formulation microemulsion are, by definition, optically clear dispersion of one physically incompatible liquid into another. The microemulsion system is turning to be more viscous with addition of water and thus may help in the slow diffusing of drug at infinite dilution. Formulation and evaluation of microemulsion based hydrogel for topical delivery article pdf available in international journal of pharmaceutical investigation 23. Pg as surfactantcosurfactant mixture scos in ratio of 15. Different concentrations of sa were incorporated in an me base composed of isopropyl. Microemulsion formulation which displayed an optical transparency of. The pseudo ternary phase diagrams were developed for combinations of karanj oil as the oil phase, span20 as surfactant and as capryol 90 as cosurfactant using water titration method. Oil and water are immiscible and they separate into two phases when mixed, each saturated with traces of the other component capek, 1999.
Formulation and evaluation of microemulsionsbased drug delivery. A microemulsion forming systems is shown in figure 1. The method is significantly more straightforward than other extant methods. Evaluation of microemulsion based hydrogel globule size determination the average droplet size of samples was measured at 25c by malvern zeta sizer. The drug is be dissolved in the lipophilic part of the microemulsion i.
Formulation consideration and characterization of microemulsion. A fluconazole wo microemulsion was developed for topical application using isopropyl myristate as the oil phase. Simultaneous presenceof two microemulsion phases, one in contact with water and the other in contact with oil is also possible. Preparation and optimization of voriconazole microemulsion. The present research work was conducted to formulate and evaluate anthralin microemulsion gel using karanj oil with an objective of improving solubility of the anthralin.
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